{
  "name": "AXED in-house research corpus",
  "updated": "2026-09-22",
  "status": "AXED in-house brief. Citations: NOT PROVIDED until a paper is attached.",
  "safety": [
    "Literature labels only. Not a systematic review.",
    "Citations: NOT PROVIDED until a paper is attached.",
    "No diagnosis, prescribing, personalized dosing, or injection instructions.",
    "Shop links are catalog rows, not recommendations."
  ],
  "themes": [
    {
      "id": "tissue-recovery",
      "label": "Tissue & recovery",
      "group": "Healing & Recovery",
      "question": "What does the directory store about tissue-repair and remodeling research?",
      "summary": "Profiles whose literature labels discuss wound, connective-tissue, or remodeling research questions. Labels are not outcome claims."
    },
    {
      "id": "gh-axis",
      "label": "Growth-hormone axis",
      "group": "Growth Hormone",
      "question": "Which stored profiles sit on the GH / GHRH / ghrelin research axis?",
      "summary": "GHRH analogs, GH secretagogues, and IGF-related listings. Half-life labels are stored literature values or NOT PROVIDED."
    },
    {
      "id": "metabolic",
      "label": "Metabolic signaling",
      "group": "Metabolic & Weight",
      "question": "What metabolic-signaling names are on file?",
      "summary": "GLP / GIP / glucagon-axis listings and lipolytic fragments. Some names have an approved indication elsewhere; AXED still does not prescribe them."
    },
    {
      "id": "cognitive",
      "label": "Cognitive & mood",
      "group": "Cognitive & Mood",
      "question": "Which cognitive and sleep-research names are stored?",
      "summary": "Neuropeptide and ACTH-related directory labels. AXED will not match a compound to a mood or diagnosis."
    },
    {
      "id": "immune-aging",
      "label": "Immune & aging",
      "group": "Immune & Longevity",
      "question": "What immune-modulation and aging-research names are stored?",
      "summary": "Mitochondrial, thymic, and telomerase-related literature labels. Longevity copy is a research theme, not a promise."
    },
    {
      "id": "reproductive",
      "label": "Reproductive & sexual",
      "group": "Sexual Health",
      "question": "Which reproductive-axis names are in the directory?",
      "summary": "GnRH- and melanocortin-related listings. AXED does not treat sexual dysfunction or recommend a compound."
    }
  ],
  "profiles": [
    {
      "id": "aod-9604",
      "name": "AOD-9604",
      "aliases": [
        "Anti-Obesity Drug 9604",
        "Tyr-hGH Fragment 177-191"
      ],
      "group": "Metabolic & Weight",
      "theme": "metabolic",
      "halfLife": "NOT PROVIDED",
      "halfLifeHours": null,
      "summary": "A modified fragment of human growth hormone studied for fat metabolism without affecting blood sugar.",
      "mechanism": "A modified fragment of the C-terminus of human growth hormone. Directory copy stores a fat-metabolism research label and notes limited overlap with full-length GH glucose effects.",
      "researchQuestions": [
        "fragment vs full-length GH",
        "lipid metabolism models"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "AXED stores a directory literature label. No trial result, effect size, or DOI is on file.",
      "relatedIds": [
        "hgh-frag-176-191",
        "mots-c"
      ],
      "studiedForm": "Research listings discuss a lyophilized research form. AXED does not publish how to prepare or administer it.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/aod-9604"
    },
    {
      "id": "bpc-157",
      "name": "BPC-157",
      "aliases": [
        "Body Protection Compound-157",
        "PL 14736"
      ],
      "group": "Healing & Recovery",
      "theme": "tissue-recovery",
      "halfLife": "~4 hours (literature-reported)",
      "halfLifeHours": 4,
      "summary": "A pentadecapeptide derived from gastric juice, studied for tissue-healing and anti-inflammatory properties.",
      "mechanism": "A fifteen-amino-acid sequence associated with gastric-juice research. Stored labels discuss tissue-repair and inflammation-signaling research questions.",
      "researchQuestions": [
        "tissue-repair models",
        "inflammation signaling"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Commonly cited in preclinical literature. AXED has not attached a paper. Citations stay NOT PROVIDED.",
      "relatedIds": [
        "bpc-157-arg",
        "tb-500",
        "ghk-cu"
      ],
      "studiedForm": "Literature discusses more than one salt and route. That is a form note, not an instruction to use any route.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/bpc-157"
    },
    {
      "id": "bpc-157-arg",
      "name": "BPC-157 Arginine Salt",
      "aliases": [
        "BPC-157 Arg",
        "BPC Oral"
      ],
      "group": "Healing & Recovery",
      "theme": "tissue-recovery",
      "halfLife": "~4 hours (literature-reported)",
      "halfLifeHours": 4,
      "summary": "An arginine salt form of BPC-157 studied for oral stability compared with the acetate form.",
      "mechanism": "An arginine salt of the same BPC-157 sequence. The directory stores an oral-stability research comparison versus the acetate form.",
      "researchQuestions": [
        "salt form vs acetate",
        "oral stability research"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Form comparison is a stored literature label. AXED does not rank salts or tell you which to use.",
      "relatedIds": [
        "bpc-157",
        "tb-500"
      ],
      "studiedForm": "Directory text mentions oral-stability research. That is not a recommendation to take it by mouth.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/bpc-157-arg"
    },
    {
      "id": "cjc-1295-no-dac",
      "name": "CJC-1295 (no DAC)",
      "aliases": [
        "Modified GRF 1-29",
        "Mod GRF"
      ],
      "group": "Growth Hormone",
      "theme": "gh-axis",
      "halfLife": "~30 minutes (literature-reported)",
      "halfLifeHours": 0.5,
      "summary": "A GHRH analog studied for GH release with a shorter duration than the DAC variant.",
      "mechanism": "A GHRH analog (modified GRF 1-29). Stored label: shorter circulating time than the DAC variant, studied for pulsatile GH-release research.",
      "researchQuestions": [
        "GHRH receptor signaling",
        "short vs long GHRH analogs"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Half-life on file is a literature-reported label (~30 minutes) or the stored string. Not a dosing interval.",
      "relatedIds": [
        "cjc-1295-dac",
        "ipamorelin",
        "sermorelin"
      ],
      "studiedForm": "Often discussed alongside a GH secretagogue in research write-ups. AXED will not build a stack.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/cjc-1295-no-dac"
    },
    {
      "id": "cjc-1295-dac",
      "name": "CJC-1295 (with DAC)",
      "aliases": [
        "CJC-1295 DAC",
        "Drug Affinity Complex"
      ],
      "group": "Growth Hormone",
      "theme": "gh-axis",
      "halfLife": "~7 days (literature-reported)",
      "halfLifeHours": 168,
      "summary": "A long-acting GHRH analog studied for sustained GH elevation due to the Drug Affinity Complex.",
      "mechanism": "The same GHRH analog with a Drug Affinity Complex. Stored label: longer circulating time, studied for sustained GH-axis questions.",
      "researchQuestions": [
        "albumin binding / DAC",
        "sustained GH-axis research"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "A ~7 day literature half-life is stored when present. It is not a weekly protocol.",
      "relatedIds": [
        "cjc-1295-no-dac",
        "tesamorelin",
        "sermorelin"
      ],
      "studiedForm": "Research listings discuss a long-acting analog. AXED does not convert that into a schedule.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/cjc-1295-dac"
    },
    {
      "id": "dihexa",
      "name": "Dihexa",
      "aliases": [
        "N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide"
      ],
      "group": "Cognitive & Mood",
      "theme": "cognitive",
      "halfLife": "~12 hours (literature-reported)",
      "halfLifeHours": 12,
      "summary": "A synthetic peptide derived from angiotensin IV, studied in cognitive and synaptogenesis research.",
      "mechanism": "A synthetic peptide derived from angiotensin IV research. Stored label: synaptogenesis and cognitive-research questions.",
      "researchQuestions": [
        "angiotensin IV analogs",
        "synapse-formation models"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Cognitive language here is a research theme, not a treatment for memory or mood.",
      "relatedIds": [
        "semax",
        "selank"
      ],
      "studiedForm": "Form and route are not stored as a protocol. Missing administration fields stay NOT PROVIDED.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/dihexa"
    },
    {
      "id": "dsip",
      "name": "DSIP",
      "aliases": [
        "Delta Sleep-Inducing Peptide"
      ],
      "group": "Cognitive & Mood",
      "theme": "cognitive",
      "halfLife": "~15 minutes (literature-reported)",
      "halfLifeHours": 0.25,
      "summary": "A neuropeptide studied for its association with delta-wave sleep in preclinical work.",
      "mechanism": "Delta sleep-inducing peptide. Stored label: association with delta-wave sleep in preclinical work.",
      "researchQuestions": [
        "sleep architecture models",
        "neuropeptide sleep research"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "A short literature half-life is stored (~15 minutes). That is not a bedtime dose.",
      "relatedIds": [
        "selank",
        "semax"
      ],
      "studiedForm": "AXED does not publish when or how to use this name.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/dsip"
    },
    {
      "id": "epithalon",
      "name": "Epithalon",
      "aliases": [
        "Epitalon",
        "Epithalamin analog"
      ],
      "group": "Immune & Longevity",
      "theme": "immune-aging",
      "halfLife": "~2 hours (literature-reported)",
      "halfLifeHours": 2,
      "summary": "A synthetic tetrapeptide based on epithalamin, studied for telomerase and aging-related research.",
      "mechanism": "A synthetic tetrapeptide based on epithalamin. Stored label: telomerase and aging-related research questions.",
      "researchQuestions": [
        "telomerase research",
        "pineal-peptide analogs"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Aging-theme copy is a directory label. AXED does not claim lifespan or reversal effects.",
      "relatedIds": [
        "mots-c",
        "thymosin-alpha-1"
      ],
      "studiedForm": "Administration is not published. Record only what you already decided, if you log at all.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/epithalon"
    },
    {
      "id": "follistatin-344",
      "name": "Follistatin 344",
      "aliases": [
        "FST-344"
      ],
      "group": "Growth Hormone",
      "theme": "gh-axis",
      "halfLife": "NOT PROVIDED",
      "halfLifeHours": null,
      "summary": "A glycoprotein that inhibits myostatin and activin, studied for muscle and fibrosis research.",
      "mechanism": "A glycoprotein that binds myostatin and activin. Stored label: muscle and fibrosis research questions.",
      "researchQuestions": [
        "myostatin / activin binding",
        "fibrosis models"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Half-life on this profile is NOT PROVIDED. AXED will not invent one.",
      "relatedIds": [
        "igf-1-lr3",
        "mgf"
      ],
      "studiedForm": "Not a training protocol. AXED will not pair this with a workout plan.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/follistatin-344"
    },
    {
      "id": "ghk-cu",
      "name": "GHK-Cu",
      "aliases": [
        "Copper tripeptide-1"
      ],
      "group": "Healing & Recovery",
      "theme": "tissue-recovery",
      "halfLife": "~30 minutes (literature-reported)",
      "halfLifeHours": 0.5,
      "summary": "A copper-binding tripeptide studied for skin regeneration, wound healing, and remodeling.",
      "mechanism": "A copper-binding tripeptide. Stored label: skin remodeling, wound, and extracellular-matrix research.",
      "researchQuestions": [
        "copper-peptide remodeling",
        "skin and wound models"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Cosmetic or topical discussion in the wider literature is not an AXED treatment claim.",
      "relatedIds": [
        "bpc-157",
        "tb-500"
      ],
      "studiedForm": "Literature mentions more than one presentation. AXED does not choose a form for you.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/ghk-cu"
    },
    {
      "id": "ghrp-2",
      "name": "GHRP-2",
      "aliases": [
        "Pralmorelin",
        "Growth Hormone Releasing Peptide-2"
      ],
      "group": "Growth Hormone",
      "theme": "gh-axis",
      "halfLife": "~30 minutes (literature-reported)",
      "halfLifeHours": 0.5,
      "summary": "A synthetic hexapeptide GH secretagogue studied at the ghrelin receptor.",
      "mechanism": "A synthetic hexapeptide GH secretagogue at the ghrelin receptor (GHS-R). Also listed as pralmorelin.",
      "researchQuestions": [
        "ghrelin-receptor secretagogues",
        "GH pulse research"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Receptor class is a stored label. AXED will not compare secretagogues as a shopping rank.",
      "relatedIds": [
        "ghrp-6",
        "hexarelin",
        "ipamorelin"
      ],
      "studiedForm": "Often discussed with a GHRH analog in research notes. AXED will not assemble that pairing as advice.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/ghrp-2"
    },
    {
      "id": "ghrp-6",
      "name": "GHRP-6",
      "aliases": [
        "Growth Hormone Releasing Peptide-6"
      ],
      "group": "Growth Hormone",
      "theme": "gh-axis",
      "halfLife": "~2.5 hours (literature-reported)",
      "halfLifeHours": 2.5,
      "summary": "A hexapeptide GH secretagogue studied for GH release and appetite signaling.",
      "mechanism": "A hexapeptide GH secretagogue. Stored label also mentions appetite-signaling research at the ghrelin axis.",
      "researchQuestions": [
        "GH release models",
        "appetite signaling"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Appetite language is a research theme, not a weight-loss recommendation.",
      "relatedIds": [
        "ghrp-2",
        "hexarelin",
        "ipamorelin"
      ],
      "studiedForm": "AXED does not publish timing relative to meals or training.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/ghrp-6"
    },
    {
      "id": "hexarelin",
      "name": "Hexarelin",
      "aliases": [
        "Examorelin"
      ],
      "group": "Growth Hormone",
      "theme": "gh-axis",
      "halfLife": "~55 minutes (literature-reported)",
      "halfLifeHours": 0.9166666666666666,
      "summary": "A potent synthetic hexapeptide GH secretagogue studied for GH release and desensitization.",
      "mechanism": "A potent synthetic hexapeptide GH secretagogue. Stored label includes GH-release and receptor-desensitization research questions.",
      "researchQuestions": [
        "GH secretagogue potency research",
        "desensitization models"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "“Potent” here describes published receptor work, not a reason to use it.",
      "relatedIds": [
        "ghrp-2",
        "ghrp-6",
        "ipamorelin"
      ],
      "studiedForm": "Desensitization language is not a cycle instruction.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/hexarelin"
    },
    {
      "id": "hgh-frag-176-191",
      "name": "HGH Fragment 176-191",
      "aliases": [
        "HGH Frag",
        "Fragment 176-191"
      ],
      "group": "Metabolic & Weight",
      "theme": "metabolic",
      "halfLife": "~30 minutes (literature-reported)",
      "halfLifeHours": 0.5,
      "summary": "The lipolytic fragment of human growth hormone studied separately from full-length HGH.",
      "mechanism": "The 176–191 region of human growth hormone, stored separately from full-length HGH. Literature label: lipolytic-fragment research.",
      "researchQuestions": [
        "GH fragment vs intact HGH",
        "lipolytic fragment research"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Not a substitute monograph for somatropin. No outcome percentage is stored.",
      "relatedIds": [
        "aod-9604",
        "tesamorelin"
      ],
      "studiedForm": "AXED does not publish a fat-loss protocol.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/hgh-frag-176-191"
    },
    {
      "id": "igf-1-des",
      "name": "IGF-1 DES",
      "aliases": [
        "Des(1-3) IGF-1"
      ],
      "group": "Growth Hormone",
      "theme": "gh-axis",
      "halfLife": "~30 minutes (literature-reported)",
      "halfLifeHours": 0.5,
      "summary": "A truncated IGF-1 analog studied for localized potency in preclinical models.",
      "mechanism": "A truncated IGF-1 analog (Des(1-3)). Stored label: localized-potency questions in preclinical models versus native IGF-1.",
      "researchQuestions": [
        "truncated IGF-1",
        "local vs circulating IGF research"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Localized-potency wording is a literature label, not a site-of-use instruction.",
      "relatedIds": [
        "igf-1-lr3",
        "mgf",
        "peg-mgf"
      ],
      "studiedForm": "AXED will not tell you where or how to apply this name.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/igf-1-des"
    },
    {
      "id": "igf-1-lr3",
      "name": "IGF-1 LR3",
      "aliases": [
        "Long R3 IGF-1",
        "Long Arg3 IGF-1"
      ],
      "group": "Growth Hormone",
      "theme": "gh-axis",
      "halfLife": "~24 hours (literature-reported)",
      "halfLifeHours": 24,
      "summary": "A modified IGF-1 analog studied for an extended half-life versus native IGF-1.",
      "mechanism": "Long Arg3 IGF-1. Stored label: extended half-life versus native IGF-1 in published analog work.",
      "researchQuestions": [
        "IGF-1 analog duration",
        "binding-protein evasion research"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "A ~24 hour literature half-life is stored when present. That is not a daily prescription.",
      "relatedIds": [
        "igf-1-des",
        "mgf",
        "follistatin-344"
      ],
      "studiedForm": "Analog comparison is educational. AXED does not pick an IGF analog.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/igf-1-lr3"
    },
    {
      "id": "ipamorelin",
      "name": "Ipamorelin",
      "aliases": [
        "NNC 26-0161"
      ],
      "group": "Growth Hormone",
      "theme": "gh-axis",
      "halfLife": "~2 hours (literature-reported)",
      "halfLifeHours": 2,
      "summary": "A selective GH secretagogue studied for GH release with limited cortisol and prolactin signal in published work.",
      "mechanism": "A selective GH secretagogue. Stored label: GH-release research with limited cortisol and prolactin signal in published work.",
      "researchQuestions": [
        "selective GHS-R agonists",
        "GH pulse research"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Selectivity language is copied from the directory summary. AXED has not attached the underlying papers.",
      "relatedIds": [
        "cjc-1295-no-dac",
        "ghrp-2",
        "hexarelin"
      ],
      "studiedForm": "Pairing talk in the wider web is not an AXED stack.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/ipamorelin"
    },
    {
      "id": "kisspeptin-10",
      "name": "Kisspeptin-10",
      "aliases": [
        "KP-10",
        "Metastin 45-54"
      ],
      "group": "Sexual Health",
      "theme": "reproductive",
      "halfLife": "~30 minutes (literature-reported)",
      "halfLifeHours": 0.5,
      "summary": "A neuropeptide studied for GnRH release and reproductive hormone regulation.",
      "mechanism": "A neuropeptide fragment (metastin 45–54). Stored label: GnRH-release and reproductive-hormone regulation research.",
      "researchQuestions": [
        "GnRH pulse research",
        "reproductive-axis peptides"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Reproductive-axis copy is not fertility treatment and not a diagnosis tool.",
      "relatedIds": [
        "pt-141"
      ],
      "studiedForm": "AXED does not publish a reproductive protocol.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/kisspeptin-10"
    },
    {
      "id": "ll-37",
      "name": "LL-37",
      "aliases": [
        "Cathelicidin",
        "Human Cathelicidin Antimicrobial Peptide"
      ],
      "group": "Immune & Longevity",
      "theme": "immune-aging",
      "halfLife": "NOT PROVIDED",
      "halfLifeHours": null,
      "summary": "An antimicrobial peptide studied in innate immunity, wound healing, and inflammation.",
      "mechanism": "Human cathelicidin antimicrobial peptide. Stored label: innate immunity, wound, and inflammation research.",
      "researchQuestions": [
        "innate immunity",
        "antimicrobial peptides"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Half-life on this profile is NOT PROVIDED. Immune language is not an infection treatment.",
      "relatedIds": [
        "thymosin-alpha-1",
        "ghk-cu"
      ],
      "studiedForm": "AXED will not advise use for an illness.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/ll-37"
    },
    {
      "id": "mgf",
      "name": "MGF",
      "aliases": [
        "Mechano Growth Factor",
        "IGF-1Ec"
      ],
      "group": "Healing & Recovery",
      "theme": "tissue-recovery",
      "halfLife": "~6 minutes (literature-reported)",
      "halfLifeHours": 0.1,
      "summary": "A splice variant of IGF-1 studied in mechanically stressed muscle tissue.",
      "mechanism": "Mechano growth factor (IGF-1Ec splice). Stored label: mechanically stressed muscle-tissue research. A very short literature half-life is on file.",
      "researchQuestions": [
        "IGF-1 splice variants",
        "mechanical-load muscle models"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "~6 minutes is a stored literature label, not a timing protocol.",
      "relatedIds": [
        "peg-mgf",
        "igf-1-des",
        "igf-1-lr3"
      ],
      "studiedForm": "PEGylated vs native comparison lives on the PEG-MGF profile. AXED does not choose between them.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/mgf"
    },
    {
      "id": "mk-677",
      "name": "MK-677",
      "aliases": [
        "Ibutamoren",
        "Nutrobal"
      ],
      "group": "Growth Hormone",
      "theme": "gh-axis",
      "halfLife": "NOT PROVIDED",
      "halfLifeHours": null,
      "summary": "An orally active ghrelin mimetic studied for sustained GH and IGF-1 elevation. It is not a peptide. Listed in the directory and marked sold out.",
      "mechanism": "Ibutamoren is an orally studied ghrelin mimetic. It is not a peptide. The directory keeps the name so search does not invent a peptide listing.",
      "researchQuestions": [
        "oral ghrelin mimetics",
        "GH / IGF-1 elevation research"
      ],
      "evidenceClass": "not-a-peptide",
      "evidenceNote": "Marked sold out in the catalog stance. AXED does not convert this into a peptide monograph.",
      "relatedIds": [
        "ipamorelin",
        "ghrp-2"
      ],
      "studiedForm": "Oral research discussion is a chemical-class note, not a reason AXED stocks or doses it.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/mk-677"
    },
    {
      "id": "mots-c",
      "name": "MOTS-C",
      "aliases": [
        "Mitochondrial ORF of the 12S rRNA Type-C"
      ],
      "group": "Immune & Longevity",
      "theme": "immune-aging",
      "halfLife": "NOT PROVIDED",
      "halfLifeHours": null,
      "summary": "A mitochondrial-derived peptide studied for metabolic homeostasis and insulin sensitivity.",
      "mechanism": "A mitochondrial-derived peptide (12S rRNA ORF). Stored label: metabolic-homeostasis and insulin-sensitivity research questions.",
      "researchQuestions": [
        "mitochondrial peptides",
        "metabolic homeostasis models"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Half-life is NOT PROVIDED on this profile. Insulin-sensitivity language is not diabetes treatment.",
      "relatedIds": [
        "nad",
        "aod-9604",
        "epithalon"
      ],
      "studiedForm": "AXED does not publish a metabolic protocol.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/mots-c"
    },
    {
      "id": "nad",
      "name": "NAD+",
      "aliases": [
        "Nicotinamide Adenine Dinucleotide"
      ],
      "group": "Immune & Longevity",
      "theme": "immune-aging",
      "halfLife": "~30 minutes (literature-reported)",
      "halfLifeHours": 0.5,
      "summary": "A coenzyme central to cellular energy metabolism and DNA repair research.",
      "mechanism": "Nicotinamide adenine dinucleotide is a coenzyme, not a peptide. Stored as a research-reference listing for energy-metabolism and DNA-repair context.",
      "researchQuestions": [
        "cellular redox cofactors",
        "NAD+ research context"
      ],
      "evidenceClass": "not-a-peptide",
      "evidenceNote": "Included so the directory can say what it is. AXED does not run an infusion protocol.",
      "relatedIds": [
        "mots-c",
        "epithalon"
      ],
      "studiedForm": "Route discussion in the wider market is not AXED administration advice.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/nad"
    },
    {
      "id": "peg-mgf",
      "name": "PEG-MGF",
      "aliases": [
        "PEGylated Mechano Growth Factor"
      ],
      "group": "Healing & Recovery",
      "theme": "tissue-recovery",
      "halfLife": "NOT PROVIDED",
      "halfLifeHours": null,
      "summary": "A PEGylated MGF analog studied for a longer circulating time than native MGF.",
      "mechanism": "PEGylated mechano growth factor. Stored label: longer circulating time than native MGF.",
      "researchQuestions": [
        "PEGylation vs native MGF",
        "extended IGF-splice research"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Half-life on this profile is NOT PROVIDED. AXED will not invent a PEG half-life.",
      "relatedIds": [
        "mgf",
        "igf-1-lr3"
      ],
      "studiedForm": "PEGylation is a chemistry note, not a schedule.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/peg-mgf"
    },
    {
      "id": "pt-141",
      "name": "PT-141",
      "aliases": [
        "Bremelanotide"
      ],
      "group": "Sexual Health",
      "theme": "reproductive",
      "halfLife": "~2.7 hours (literature-reported)",
      "halfLifeHours": 2.7,
      "summary": "A melanocortin receptor agonist studied for sexual dysfunction via central pathways.",
      "mechanism": "Bremelanotide, a melanocortin-receptor agonist. Stored label: central-pathway sexual-function research.",
      "researchQuestions": [
        "melanocortin agonists",
        "central sexual-function research"
      ],
      "evidenceClass": "reference-listing",
      "evidenceNote": "A named analog exists in clinical use in some jurisdictions. AXED still lists a research profile and will not treat sexual dysfunction.",
      "relatedIds": [
        "kisspeptin-10"
      ],
      "studiedForm": "AXED does not publish how this name is used clinically or otherwise.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/pt-141"
    },
    {
      "id": "retatrutide",
      "name": "Retatrutide",
      "aliases": [
        "LY3437943",
        "Reta"
      ],
      "group": "Metabolic & Weight",
      "theme": "metabolic",
      "halfLife": "NOT PROVIDED",
      "halfLifeHours": null,
      "summary": "An investigational triple agonist studied at GIP, GLP-1, and glucagon receptors.",
      "mechanism": "An investigational triple agonist studied at GIP, GLP-1, and glucagon receptors (LY3437943).",
      "researchQuestions": [
        "triple incretin / glucagon agonism",
        "investigational metabolic analogs"
      ],
      "evidenceClass": "investigational",
      "evidenceNote": "Investigational status is stored. AXED will not invent trial percentages, doses, or approval claims.",
      "relatedIds": [
        "tirzepatide",
        "semaglutide"
      ],
      "studiedForm": "Not a substitute for an approved metabolic medicine. AXED does not prescribe either.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/retatrutide"
    },
    {
      "id": "selank",
      "name": "Selank",
      "aliases": [
        "Tuftsin analog"
      ],
      "group": "Cognitive & Mood",
      "theme": "cognitive",
      "halfLife": "NOT PROVIDED",
      "halfLifeHours": null,
      "summary": "A synthetic tuftsin analog studied for anxiolytic and nootropic research questions.",
      "mechanism": "A synthetic tuftsin analog. Stored label: anxiolytic and nootropic research questions.",
      "researchQuestions": [
        "tuftsin analogs",
        "anxiolytic research models"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Anxiety-theme copy is not a diagnosis and not a substitute for care.",
      "relatedIds": [
        "semax",
        "dsip"
      ],
      "studiedForm": "Intranasal discussion in the wider literature is not an AXED instruction.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/selank"
    },
    {
      "id": "semaglutide",
      "name": "Semaglutide",
      "aliases": [
        "GLP-1 RA"
      ],
      "group": "Metabolic & Weight",
      "theme": "metabolic",
      "halfLife": "NOT PROVIDED",
      "halfLifeHours": null,
      "summary": "A GLP-1 receptor agonist used clinically for type 2 diabetes and weight management. Listed here as a research reference only.",
      "mechanism": "A GLP-1 receptor agonist. Stored as a research reference because an approved clinical use exists for type 2 diabetes and weight management in some jurisdictions.",
      "researchQuestions": [
        "GLP-1 receptor agonists",
        "incretin reference listings"
      ],
      "evidenceClass": "approved-indication-exists",
      "evidenceNote": "Reference listing only. AXED is not a pharmacy for this name and will not dose it.",
      "relatedIds": [
        "tirzepatide",
        "retatrutide"
      ],
      "studiedForm": "Approved-product use is a matter for a licensed clinician. AXED will not copy a clinic schedule.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/semaglutide"
    },
    {
      "id": "semax",
      "name": "Semax",
      "aliases": [
        "ACTH 4-10 analog"
      ],
      "group": "Cognitive & Mood",
      "theme": "cognitive",
      "halfLife": "NOT PROVIDED",
      "halfLifeHours": null,
      "summary": "A synthetic ACTH(4-10) analog studied for neuroprotective and cognitive research.",
      "mechanism": "A synthetic ACTH(4–10) analog. Stored label: neuroprotective and cognitive-research questions.",
      "researchQuestions": [
        "ACTH fragment analogs",
        "cognitive research models"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Neuroprotection wording is a literature theme, not a stroke or cognition treatment.",
      "relatedIds": [
        "selank",
        "dihexa"
      ],
      "studiedForm": "Route talk elsewhere is not an AXED protocol.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/semax"
    },
    {
      "id": "sermorelin",
      "name": "Sermorelin",
      "aliases": [
        "GRF 1-29",
        "Geref"
      ],
      "group": "Growth Hormone",
      "theme": "gh-axis",
      "halfLife": "NOT PROVIDED",
      "halfLifeHours": null,
      "summary": "A GHRH analog of the first 29 amino acids of endogenous GHRH, studied for pituitary GH release.",
      "mechanism": "GHRH 1–29 (Geref in historical labeling). Stored label: pituitary GH-release research.",
      "researchQuestions": [
        "endogenous GHRH fragment",
        "pituitary GH-release research"
      ],
      "evidenceClass": "reference-listing",
      "evidenceNote": "Half-life on this profile is NOT PROVIDED. Historical clinical naming does not make AXED a prescriber.",
      "relatedIds": [
        "cjc-1295-no-dac",
        "tesamorelin"
      ],
      "studiedForm": "AXED does not reconstruct a historical clinic protocol.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/sermorelin"
    },
    {
      "id": "tb-500",
      "name": "TB-500",
      "aliases": [
        "Thymosin Beta-4",
        "TB4"
      ],
      "group": "Healing & Recovery",
      "theme": "tissue-recovery",
      "halfLife": "NOT PROVIDED",
      "halfLifeHours": null,
      "summary": "A synthetic fragment of thymosin beta-4 studied for wound healing and tissue repair.",
      "mechanism": "A synthetic fragment associated with thymosin beta-4 research. Stored label: wound-healing and tissue-repair questions.",
      "researchQuestions": [
        "thymosin beta-4 fragments",
        "repair and remodeling models"
      ],
      "evidenceClass": "preclinical-literature",
      "evidenceNote": "Often discussed next to BPC-157 in informal writing. AXED stores both names and will not sell a pair as a protocol.",
      "relatedIds": [
        "bpc-157",
        "ghk-cu",
        "bpc-157-arg"
      ],
      "studiedForm": "Blend SKUs in a shop, if they exist, are catalog rows — not a recommended stack.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/tb-500"
    },
    {
      "id": "tesamorelin",
      "name": "Tesamorelin",
      "aliases": [
        "Egrifta"
      ],
      "group": "Growth Hormone",
      "theme": "gh-axis",
      "halfLife": "~26 minutes (literature-reported)",
      "halfLifeHours": 0.43333333333333335,
      "summary": "A GHRH analog studied and used to reduce visceral adipose tissue in a specific approved indication.",
      "mechanism": "A GHRH analog. Stored label: studied and used to reduce visceral adipose tissue in a specific approved indication (Egrifta naming in some markets).",
      "researchQuestions": [
        "GHRH analogs",
        "visceral-adipose research indication"
      ],
      "evidenceClass": "approved-indication-exists",
      "evidenceNote": "The approved indication is named as context. AXED does not evaluate whether it applies to anyone here.",
      "relatedIds": [
        "cjc-1295-dac",
        "sermorelin",
        "hgh-frag-176-191"
      ],
      "studiedForm": "Approved-product use stays with a licensed clinician. AXED will not copy that label into a DIY schedule.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/tesamorelin"
    },
    {
      "id": "thymosin-alpha-1",
      "name": "Thymosin Alpha-1",
      "aliases": [
        "TA1",
        "Zadaxin"
      ],
      "group": "Immune & Longevity",
      "theme": "immune-aging",
      "halfLife": "NOT PROVIDED",
      "halfLifeHours": null,
      "summary": "An immune-modulating peptide studied for T-cell function and immune surveillance.",
      "mechanism": "An immune-modulating peptide (TA1 / Zadaxin naming in some markets). Stored label: T-cell function and immune-surveillance research.",
      "researchQuestions": [
        "thymic peptides",
        "T-cell research"
      ],
      "evidenceClass": "reference-listing",
      "evidenceNote": "Immune-surveillance language is not infection or cancer treatment on AXED.",
      "relatedIds": [
        "ll-37",
        "epithalon"
      ],
      "studiedForm": "AXED does not publish an immune protocol.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/thymosin-alpha-1"
    },
    {
      "id": "tirzepatide",
      "name": "Tirzepatide",
      "aliases": [
        "Dual GIP/GLP-1 RA"
      ],
      "group": "Metabolic & Weight",
      "theme": "metabolic",
      "halfLife": "NOT PROVIDED",
      "halfLifeHours": null,
      "summary": "A dual GIP/GLP-1 receptor agonist used clinically for diabetes and weight management. Reference listing only.",
      "mechanism": "A dual GIP / GLP-1 receptor agonist. Stored as a research reference because approved clinical use exists in some jurisdictions.",
      "researchQuestions": [
        "dual incretin agonists",
        "metabolic reference listings"
      ],
      "evidenceClass": "approved-indication-exists",
      "evidenceNote": "Reference listing only. AXED will not dose, titrate, or compare it as a product to buy here.",
      "relatedIds": [
        "semaglutide",
        "retatrutide"
      ],
      "studiedForm": "Clinic titration schedules are not reproduced. Calculators will not invent one.",
      "citations": "NOT PROVIDED",
      "path": "/peptides/tirzepatide"
    }
  ],
  "landscape": {
    "updated": "2026-09-22",
    "status": "AXED in-house brief. Citations: NOT PROVIDED until a paper is attached.",
    "total": 34,
    "byGroup": [
      {
        "theme": "Tissue & recovery",
        "themeId": "tissue-recovery",
        "group": "Healing & Recovery",
        "count": 6
      },
      {
        "theme": "Growth-hormone axis",
        "themeId": "gh-axis",
        "group": "Growth Hormone",
        "count": 12
      },
      {
        "theme": "Metabolic signaling",
        "themeId": "metabolic",
        "group": "Metabolic & Weight",
        "count": 5
      },
      {
        "theme": "Cognitive & mood",
        "themeId": "cognitive",
        "group": "Cognitive & Mood",
        "count": 4
      },
      {
        "theme": "Immune & aging",
        "themeId": "immune-aging",
        "group": "Immune & Longevity",
        "count": 5
      },
      {
        "theme": "Reproductive & sexual",
        "themeId": "reproductive",
        "group": "Sexual Health",
        "count": 2
      }
    ],
    "byEvidence": [
      {
        "key": "preclinical-literature",
        "label": "Preclinical literature label",
        "count": 25
      },
      {
        "key": "investigational",
        "label": "Investigational listing",
        "count": 1
      },
      {
        "key": "approved-indication-exists",
        "label": "Approved indication exists (reference)",
        "count": 3
      },
      {
        "key": "reference-listing",
        "label": "Reference listing only",
        "count": 3
      },
      {
        "key": "not-a-peptide",
        "label": "Not a peptide",
        "count": 2
      }
    ],
    "halfLives": [
      {
        "id": "mgf",
        "name": "MGF",
        "group": "Healing & Recovery",
        "hours": 0.1,
        "label": "~6 minutes (literature-reported)"
      },
      {
        "id": "dsip",
        "name": "DSIP",
        "group": "Cognitive & Mood",
        "hours": 0.25,
        "label": "~15 minutes (literature-reported)"
      },
      {
        "id": "tesamorelin",
        "name": "Tesamorelin",
        "group": "Growth Hormone",
        "hours": 0.43333333333333335,
        "label": "~26 minutes (literature-reported)"
      },
      {
        "id": "cjc-1295-no-dac",
        "name": "CJC-1295 (no DAC)",
        "group": "Growth Hormone",
        "hours": 0.5,
        "label": "~30 minutes (literature-reported)"
      },
      {
        "id": "ghk-cu",
        "name": "GHK-Cu",
        "group": "Healing & Recovery",
        "hours": 0.5,
        "label": "~30 minutes (literature-reported)"
      },
      {
        "id": "ghrp-2",
        "name": "GHRP-2",
        "group": "Growth Hormone",
        "hours": 0.5,
        "label": "~30 minutes (literature-reported)"
      },
      {
        "id": "hgh-frag-176-191",
        "name": "HGH Fragment 176-191",
        "group": "Metabolic & Weight",
        "hours": 0.5,
        "label": "~30 minutes (literature-reported)"
      },
      {
        "id": "igf-1-des",
        "name": "IGF-1 DES",
        "group": "Growth Hormone",
        "hours": 0.5,
        "label": "~30 minutes (literature-reported)"
      },
      {
        "id": "kisspeptin-10",
        "name": "Kisspeptin-10",
        "group": "Sexual Health",
        "hours": 0.5,
        "label": "~30 minutes (literature-reported)"
      },
      {
        "id": "nad",
        "name": "NAD+",
        "group": "Immune & Longevity",
        "hours": 0.5,
        "label": "~30 minutes (literature-reported)"
      },
      {
        "id": "hexarelin",
        "name": "Hexarelin",
        "group": "Growth Hormone",
        "hours": 0.9166666666666666,
        "label": "~55 minutes (literature-reported)"
      },
      {
        "id": "epithalon",
        "name": "Epithalon",
        "group": "Immune & Longevity",
        "hours": 2,
        "label": "~2 hours (literature-reported)"
      },
      {
        "id": "ipamorelin",
        "name": "Ipamorelin",
        "group": "Growth Hormone",
        "hours": 2,
        "label": "~2 hours (literature-reported)"
      },
      {
        "id": "ghrp-6",
        "name": "GHRP-6",
        "group": "Growth Hormone",
        "hours": 2.5,
        "label": "~2.5 hours (literature-reported)"
      },
      {
        "id": "pt-141",
        "name": "PT-141",
        "group": "Sexual Health",
        "hours": 2.7,
        "label": "~2.7 hours (literature-reported)"
      },
      {
        "id": "bpc-157",
        "name": "BPC-157",
        "group": "Healing & Recovery",
        "hours": 4,
        "label": "~4 hours (literature-reported)"
      },
      {
        "id": "bpc-157-arg",
        "name": "BPC-157 Arginine Salt",
        "group": "Healing & Recovery",
        "hours": 4,
        "label": "~4 hours (literature-reported)"
      },
      {
        "id": "dihexa",
        "name": "Dihexa",
        "group": "Cognitive & Mood",
        "hours": 12,
        "label": "~12 hours (literature-reported)"
      },
      {
        "id": "igf-1-lr3",
        "name": "IGF-1 LR3",
        "group": "Growth Hormone",
        "hours": 24,
        "label": "~24 hours (literature-reported)"
      },
      {
        "id": "cjc-1295-dac",
        "name": "CJC-1295 (with DAC)",
        "group": "Growth Hormone",
        "hours": 168,
        "label": "~7 days (literature-reported)"
      }
    ],
    "missingHalfLife": 14,
    "note": "Counts are directory composition, not popularity, efficacy, or stock. Half-life hours are parsed from stored literature labels only."
  }
}